Abstract

INVESTIGATION OF HEPATOPROTECTIVE ACTIVITY OF D-PINITOL IN PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

Niraj Narendra Terkar* and Dr. Lahu D. Hingane

ABSTRACT

Hepatotoxicity is the term used to describe the harm or impairment inflicted on the liver as a result of being exposed to specific drugs or substances. It is considered an adverse drug reaction that, although uncommon, can be quite serious. Currently, there is no specific treatment available for hepatotoxicity, and the primary approach involves discontinuing the suspected drug and managing the symptoms that arise. In this context, the aim of the present study was to investigate the potential hepatoprotective activity of D-Pinitol by assessing hepatic biochemical markers. Previous studies have indicated that treatment with Paracetamol can lead to an increase in the weight of the liver in rats. Additionally, the administration of Paracetamol has been observed to elevate the levels of certain serum markers such as alanine transaminase, aspartate transaminase, total bilirubin and hepatic parenchyma. However, in contrast, the use of D-Pinitol had no significant effect on the weight of the rats' livers and maintained normal levels of these aforementioned variables. Based on the findings of this study, it can be concluded that D-Pinitol exhibits protective effects against hepatotoxicity, as evidenced by the maintenance of normal hepatic biochemical markers. D-Pinitol appears to mitigate the impact of oxidative stress and pro-inflammatory cytokines on the liver, thereby safeguarding it from drug-induced damage. These results highlight the potential therapeutic value of D-Pinitol in the prevention or management of hepatotoxicity, although further research is warranted to elucidate the underlying mechanisms and confirm its clinical applicability.

Keywords: Hepatoprotective Activity, D-Pinitol, Paracetamol, Hepatotoxicity.