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FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET CONTAINING ATORVASTATIN SOLID DISPERSION
Mohammad Zameeruddin, Kishor R. Rajmalle*, Jadhav S.B., Bharkad V.B.,Kadam V.S.
ABSTRACT
Atorvastatin calcium is a poorly water soluble oral Cardivascular agent. The Atorastatin belongs to BCS class II drug having low solubility and high permeability. In the present study attempt was made to improve solubility and dissolution rate of poorly soluble drug by solid dispersion technique using hydrophilic carriers such as Soluplus and Ghatti gum. according to carrier in which one of the synthetic/artificial polymer (soluplus) and other is natural polymer (Ghatti gum). The FTIR study indicates that there is no interaction between drug and polymers. The solid dispersions were prepared by solvent Evaporation method in three different ratios viz.1:1, 1:2, and 1:4. The prepared solid dispersions were evaluated for physical appearance, solubility study, drug content, and in-vitro dissolution study. The optimized batches is AS2 and AG1 which shows 98.64%, 94.67% drug release within 60 min and solubility was 23.09μg/ml,21.64μg/ml respectively hence observed that synthetic polymer shows higher solubility and dissolution rate than natural polymer hence optimized batches of solid dispersion formulation of Immediate release tablet. Keywords: Atorvastatin calcium, solid dispersion, solvent evaporation method. [Download Article] [Download Certifiate] |