![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
FORMULATION, EVALUATION & CHARACTERIZATION OF COMPRESSED TABLET LOZENGES
Y. A. Patil*, A. A. Sheikh and K. R. Biyani
ABSTRACT The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lisinopril, using Gelatin, Acacia and talc. Lisinopril is an angiotensin-converting enzyme inhibitor medication used to treat highblood pressure, heart failure, and heart attacks. Lisinopril has low bioavailability; to overcome this demerit the desiredmodified released formulation is needed. The Lozenges have a number of challenges in improving oral bioavailability and compliance with patients. For this purpose, one approach was adopted namely compress tablet lozenges of Lisinopril. The preformulation studied was performed in terms of organoleptic properties, melting point, solubility test, and the spectrometric determination of Lisinopril. It was found that Lisinopril was detected at wavelength 210 nm. The Lisinopril was linear over the concentration range of 10-50ug/mL. The drug and Excipient interaction was carried out by using FT-IR studies, which the gives observation there is no extra peak hence the drug and excipient were suitable for each other. The Compressed tablet lozenges were prepared with different batches of formulation F1-F6 using the wet granulation method and two binders Gelatin and Acacia. Then on the compressed tablet lozenges, post-compression parameters were carried out. The prepared Tablet lozenges have an admirable thickness, and hardness also all formulations pass the weight variation test and friability test. Also, the prepared all F1-F6 formulation gives proper dissolution profile as the concentration of binder. The formulation F5 gives a disintegration time of 16 min with % a drug release of 98.9%. As per the drug kinetics study, all formulations obey zero-order kinetics when compared with different models. Keywords: Lisinopril, Bioavailability, Bilayer tablet etc. [Download Article] [Download Certifiate] |