Abstract

A SYSTEMATIC REVIEW ON SWERTIA CHIRATA- A POTENTIAL HERBAL REMEDY

Prince Kumar Saini*, Mukesh Kumar, Shamim and Prabhakar Vishvakarma

ABSTRACT

Drug accessibility and appropriate medication use are crucial components of effective primary care. Swertia chirata is one of many herbal plants that have been employed in traditional medicine. It is a long-used herb that was first brought to Europe in 1839. Swertia, a member of the Gentianaceae family, was initially described by Roxburgh in 1814 under the name Gentiana chyrayta. The present review was based on the literature survey of various phytochemicals, pharmacological potentials found in the Swertia chirata shrub through using PubMed, Scopus, and other reputed sources. A wide variety of pharmacologically bioactive compounds, including xanthones and their derivatives, lignans, alkaloids, flavonoids, terpenoids, iridoids, secoiridoids, and other compounds like chiratin, ophelic acid, palmitic acid, oleic acid, and stearic acid, are responsible for S. chirayita's wide-ranging biological activities. Amarogentin, swertiamarin, mangiferin, swerchirin, sweroside, amaroswerin, and gentiopicrin are just some of the primary phytoconstituents that have been linked to pharmacological efficacy of S. chirata. In ancient time, it had shown numerous traditional uses like anthelmintic, hepatoprotective, hypoglycaemic, antimalarial, antifungal, antibacterial, cardio stimulant, antifatigue, anti-inflammatory, antiaging, antidiarrheal, heart protector, and blood-pressure and blood-sugar-lowering agent. It concludes that whole shrub of S. chirata is a rich source of many chemical moieties that are responsible for their variety of pharmacological potentials. It might be given in human being once the successful toxicity studies performed preclinically. S. chirata is one of the promising shrubs for versatile research.

Keywords: Swertia chirata, phytochemicals, swertiamarin, mangiferin, pharmacological activity.