Abstract

A REVIEW ON COMPARATIVE SCREENING OF ANALYTICAL METHODS FOR THE ESTIMATION OF CEFPODOXIME PROXITIL IN PHARMACEUTICAL FORMULATION AND BIOLOGICAL MATRICES

Dr. T. Ethiraj*, R. Revathi and V. Ganesan

ABSTRACT

Cefpodoxime proxetil (CP) is a third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis. CP is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. Thus, innumerable research studies have been conducted and published to estimate CP because of their contribution to its biological and pharmacological activity. This review article represents the collection and discussion of numerous analytical methods available in the literature for the determination of CP in pharmaceutical formulation and biological samples comprising of HPLC, HPTLC, UV-Visible spectroscopic method and hyphenated technique such as LC-MS. This brief review is intended to steer the various analytical methods and recent developments implemented for the analysis of CP content in formulation and in combination with other drugs, which are indeed being explored for the future analytical study of CP.

Keywords: Cephalosporin, Analytical methods, Comparative screening, ICH guidelines.