Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG BY SPHERICAL CRYSTALLIZATION TECHNIQUE

Prince Kumar, Anna Balaji and Shaheen Sultana*

ABSTRACT

In the world of pharmacy, Kawashima created the spherical crystallization process for increasing the size of drugs in 1986. This article investigates the use of spherical crystallization as a method for enhancing the solubility of a poorly water-soluble drug. The data show that the use of this technique significantly improves the solubility of the drug, making it more bioavailable and easier to administer. Along with this, other applications of spherical crystallization technique are also discussed like masking the bitter taste of drugs and increasing the flowability and compressibility of drugs among others. Several methods that can be used to achieve spherical crystallization of drugs are also highlighted. This article also discusses the potential for this method to be applied to other poorly water-soluble drugs, highlighting its potential as a widely applicable solution for improving drug solubility and the factors that influence the outcome of spherical crystallization. The studies that have been conducted on the use of spherical crystallization for enhancing the solubility of poorly water-soluble drugs have also been discussed.

Keywords: Spherical crystallization, solubility enhancement, drug solubility, poorly water-soluble drugs.