Abstract

INNOVATIVE TREATMENTS STRATEGIES FOR THE MANAGEMENT OF PSORIASIS: EMERGING TRENDS AND PERSPECTIVES

Siddhant Rai, Anna Balaji and Shaheen Sultana*

ABSTRACT

Background: An immune-mediated dermatological illness featuring recurrent episodes is acknowledged as psoriasis. Around the world, 1%–3% of people suffer from the autoimmune skin condition recognised as psoriasis. Systemic therapy, phototherapy, and topical therapywith immunosuppressive activity are some of the numerous therapeutic agents that have the potential to treat psoriasis. There are numerous barriers to effective psoriasis treatment, including poor drug delivery and poor efficacy after receiving traditional pharmaceutical therapies. Objective: In this article, we go through the traditional therapy in conjunction with nano-based drug delivery systems to treat psoriasis. The management of psoriasis utilising medications in conjunction with innovative drug delivery technologies is the target of this review. Method: In this review, we present a comprehensive view of various nanotechnology approaches which enables skin targeting, increases effectiveness, and reduces side effects. To address psoriasis, numerous nanocarriers were discovered, including liposomes, ethosomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, and microspheres. Result: Each individual nanocarrier was investigated to determine its features, benefits, and applicability when used as an anti-psoriatic drug. Furthermore; there are relatively few patents that incorporate a nanocarrier system for the treatment of psoriasis in the field of nanotechnology. Conclusion: Nanocarriers have been thoroughly researched for psoriasis because to their great preclinical outcomes, despite their limited achievement in market translatability.

Keywords: Nanocarrier, Psoriasis, Drug delivery systems, Pathophysiology, conventional, Liposomes.