Abstract

FORMULATION AND EVALUATION OF NOVEL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF XEROSTOMIA

P. A. Nitnaware* and A. C. Menkudale

ABSTRACT

The aim of present study was to provide palliative treatment for Xerostomia using speronized extrudates a novel drug delivery system. Xerostomia is condition where salivary gland dysfunction is associated with decreased secretion, or more often, qualitative changes in saliva proteins and immunoglobulin concentrations. The most frequently reported causes of xerostomia are taking medications, diseases such as Sjögren's syndrome or radiotherapy. Complications of xerostomia include dental caries, candidiasis or difficulty with the use of dentures. The clinician needs to identify the possible cause and provide the patient with appropriate treatment. Remedies for xerostomia usually are palliative but may offer some protection from the condition's more significant complications. Herbal remedies are alternative medicines are gaining popularity and recognition within the professional community. Several herbal drugs have been recently developed and used in clinical trials successfully to relieve xerostomia. However, only a few reports are published on these herbs. Hence, we used an antioxidant Hibiscusss abdariffa L. (roselle) which has Sialogogue potential useful for healing of mouth ulcers and treatment of inflammatory reactions of salivary gland with most commonly cited herbal product Zingiber officinale (Zingiberaceae). The speronized extrudates of Hibiscusss abdariffa L. (roselle) with Zingiber officinale Ross. shows highest Sialogogue activity.

Keywords: Palliative, Xerostomia, Speronized extrudates, Sjögren's syndrome, Sialogogue.