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CLINICAL PHARMACOLOGY OF AMINOGLYCOSIDES IN INFANTS AND CHILDREN
Gian Maria Pacifici*
ABSTRACT
The aminoglycosides used in paediatric patients are gentamicin, tobramycin, amikacin, and streptomycin. Aminoglycosides are potent and useful antibiotics and their activity is mainly against aerobic gram-negative bacteria. Aminoglycosides are rapidly bactericidal being inhibitors of bacterial cell protein synthesis and the bacterial killing-rate is concentration dependent, the higher the concentration the greater bacterial killing-rate. The inhibitory activity of aminoglycosides persist after their serum concentrations fall below the MIC of bacteria a phenomenon known as the “post-antibiotic effect”. Aminoglycosides are used to treat urinary-tract infections, pneumonia, meningitis, peritonitis, bacterial endocarditis, tularaemia, plague, Keywords: Aminoglycosides, concentration, dosing, drug-interactions, nephrotoxicity, ototoxicity, pharmacokinetics, therapeutic-indications, and variability. [Download Article] [Download Certifiate] |