Abstract

SAIKOSAPONIN, A NATURAL IMMUNOSUPPRESSANT - USED AS A SUPPLEMENT TO TARGET HYPERCYTOKINEMIA AND CONTROL HYPERGLYCEMIA INDUCED BY STEROID

Hari Prasath D.*

ABSTRACT

The Coronavirus become the most infectious illness of this twentieth-century scaring the entire world and being proclaimed a pandemic by the WHO. The novel zoonotic infection goes into have cell through endocytosis. Covid is a huge group of infections brought about by extreme intense respiratory condition Covid 2(SARS-COV-2) infection strain that arose out of Wuhan, China. Mortality in Coronavirus patients has been connected to the presence of a "cytokine storm" incited by infection. The current review is figured out with a review and dissecting the dash of the first and second wave and focusing on the hypercytokinemia to oversee steroid-induced hyperglycemia. The review information was gathered from the case report types of patients and given the writing overview. Saikosaponin is a homegrown medication known to diminish favorable to incendiary cytokines and chemokines (IL-2, IL-4, IL-5, IL-6, IL-8, IFN-γ, and TNF-α) framed by macrophages and upregulation of provocative responses. The Saikosapanin component of activity is as yet not completely perceived. In our review, we noticed the use of steroids in the first and second rush of COVID-19 patients, from this utilization of steroids, was high in the second wave than in the first wave. use of steroids brings about steroid-initiated hyperglycemia in a portion of the cases to stay away from this aftereffect we propose the utilization of Saikosapanin as a supplement which will lessen the steroid prompted hyperglycemia impact. As indicated by our overview Saikosapanin has immunomodulatory, mitigating action. Pretty much COVID 19 side effects and its disease was like seasonal infection so we recommend that saikosaponin might be utilized as a supplement to lessen the aggravation in lungs and it evades post COVID condition for example Steroid incited hyperglycemia.

Keywords: Covid 19, cytokine storm, Steroid therapy, Hyperglycemia, Saikosaponin, immunosuppressant activity.