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FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DOLUTEGRAVIR
Dr. Shaik Shabbeer*, M. Roopa Rani, A. Vaishnavi, U. Sandhya Rani, SK. Subanbee, B. Suchithra, MD. Firdous Khan, Dr. CH. V. Suresh and Dr. K. N. V. Rao
ABSTRACT The present investigation was to develop Dolutegravir controlled release 250 mg matrix tablets. Dolutegravir is a second generation HIV integrase strand transfer inhibitor (INSTI). Six formulations of Dolutegravir 250 mg were formulated by direct comparison using different polymers like Hupu gum, Gum Karaya & HPMC were used as rate controlling step. The formulation F2 was selected as an optimised formulation because it gives best results in terms in vitro drug release in controlled manner. Keywords: Dolutegravir, Controlled release, Matrix tablets, Hupu gum, Gum karaya & HPMC. [Download Article] [Download Certifiate] |