Abstract

DRUG UTILIZATION PATTERN AND ADVERSE DRUG REACTION MONITORING OF DRUGS USED IN TYPHOID AT A TERTIARY CARE HOSPITAL: A PROSPECTIVE OBSERVATIONAL STUDY

Mulayam Singh, Dr. Mohammad Khushtar*, Mohd. Ajmal, Mohammad Shamveel Javed, Fayeq Siddique, Abu Raihan Shams, Dr. Mukhtar Ahmad, Md. Nematullah, Fauzia Khan

ABSTRACT

Background: Salmonella enterica serotype Typhi (S. Typhi) is a bacterial pathogen responsible for typhoid fever, a systemic infection with significant global morbidity and mortality. Understanding drug utilization patterns and adverse drug reactions (ADRs) in managing typhoid fever is essential for rational drug use and patient safety. Methods: A prospective observational study was conducted over six months at a tertiary care hospital in Lucknow, India, involving 100 typhoid patients. The study aimed to evaluate the antibiotics prescribed, assess drug utilization patterns, and identify associated ADRs. Results: Ceftriaxone was the most frequently prescribed antibiotic, predominantly administered as monotherapy, followed by combination therapy. The study population predominantly consisted of male patients, with the highest incidence observed in the 40-50 age group. The most common ADR reported was nausea, followed by abdominal pain, rigor, rash, and thrombophlebitis. The findings underscore the importance of monitoring ADRs and implementing preventive measures for optimal patient care. Conclusion: This study provides valuable insights for healthcare providers, enabling them to make informed decisions regarding the selection, administration, and monitoring of antibiotics in the management of typhoid fever. Continuous surveillance of ADRs and adherence to rational prescribing practices are crucial for improving treatment outcomes and ensuring patient safety.

Keywords: Drug Utilization Pattern (DUP), Adverse Drug Reactions (ADRs), Antibiotic Therapy, Typhoid Fever.