Abstract

FORMULATION AND CHARACTERIZATION OF NATEGLINIDE LOADED MICROSPHERES

*K. Kiruthiga, Dr. L. Karpagavalli and Dr. C. Roosewelt

ABSTRACT

The aim of the present study was to prepare and characterize microspheres containing Nateglinide to improve the therapeutic efficacy and reducing the frequent dosing. solvent diffusion method was employed using Eudragit RS 100 as a polymer with various drug- polymer ratio for the preparation of microspheres. Characterization techniques followed for the formed microspheres were chemical compatibility study, percentage yield, drug content, entrapment efficiency, particle size analysis, morphology, in vitro drug release and kinetic study. It was found that there was no chemical interaction between drug and polymers used as per FTIR results. The drug–polymer ratio showed remarkable impact on drug content, entrapment efficiency. SEM micrographs revealed that microsphere are Circular in shape with smooth surface. The microsphere were then loaded in capsules followed by invitro drug release study; which depicted that microsphere with drug -polymer ratio 1:5 was more proficient to give controlled release at the end of 12 h. The kinetics analysis of the drug release from the microspheres follows Zero order and anomalous (non-Fickian) transport mechanism.

Keywords: Microspheres, Nateglinide, Solvent Diffusion Method, (Eudragit RS 100/Ethyl Cellulose), invitro drug release.