UV SPECTROPHOTOMETRIC ESTIMATION OF PHENAZONE IN BULK AND TABLET DOSAGE FORM BY AUC METHOD
Saurabh S. Arale*, Manisha S. Phoujdar, Shwetal P. Vassa
ABSTRACT
A simple, precise, accurate, and economical UV visible
spectrophotometric method has been developed for estimation of
Phenazone drug by AUC method. The standard and sample solutions
were prepared by using double distilled water as a solvent.
Quantitative determination of the drug was performed at wavelength
range 232-252 nm. The linearity was established over the
concentration range of 10-30 μg/ml for Phenazone with correlation
coefficient value of 0.9998. Precision studies showed that % relative
standard deviation was within range of acceptable limits. The mean
percentage recovery was found to be 99.905%. The proposed method
has been validated as per ICH guidelines
Keywords: Phenazone, UV visible spectrophotometry, AUC, Method Validation.
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