Abstract

FORMULATION AND CHARACTERIZATION OF ROPINIROLE HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES

D. Kishore Kumar*, Dr. L. Karpagavalli, Dr. C. Roosewelt

ABSTRACT

The aim of the present study was to prepare and characterize Solid lipid nanoparticles containing Ropinirole Hydrochloride to improve the therapeutic efficacy and reducing the frequent dosing. Double emulsion method was employed using stearic acid as a lipid with various drug-lipid ratios for the preparation of solid lipid nanoparticles. Characterization techniques followed for the formed solid lipid nanoparticles were chemical compatibility study, percentage yield, drug content, entrapment efficiency, particle size analysis, morphology, in vitro drug release and kinetic study. It was found that there was no chemical interaction between drug and polymers used as per FTIR results. The drug –lipid ratio showed remarkable impact on drug content, entrapment efficiency. SEM micrographs revealed that solid lipid nanoparticles are Circular in shape with smooth surface. The solid lipid nanoparticles were then loaded in capsules followed by invitro drug release study; which depicted that solid lipid nanoparticle with drug - lipid ratio 1:7 was more proficient to give controlled release at the end of 12 h. The kinetics analysis of the drug release from the solid lipid nanoparticles follows Zero order and anomalous (non-Fickian) transport mechanism.

Keywords: Solid Lipid Nanoparticles, Ropinirole Hydrochloride, Double emulsion method, Stearic acid, in vitro drug release.