Abstract

PREPARATION AND EVALUATION OF POLYHERBAL ANTISEPTIC CREAM

Shashank Ranjan Pandey*, Prabhudutta Panda and Abhay Sagar

ABSTRACT

In the developed world, herbal drugs and therapies are used extensively in both conventional and alternative medicine. Among the symptoms for which traditional herbal medicines are most commonly used are skin and skin-related disorders. The physicochemical properties of the formulations, including loss of drying, pH, spreadability, extrudability, and diffusion experiments, were then looked at, and the results were encouraging. The formulations also remained stable at 4°C, 25°C, and 37°C. Additionally, the antibacterial potency of polyherbal formulations was examined against Staphylococcus aureus, Pseudomonas sp., and Bacillus sp. using the agar diffusion technique and betadine (5%w/w) as the reference. The majority of the formulations demonstrated efficacy against specific species. Additionally, the antioxidant activity of the formulations was assessed using the reducing power test, nitric oxide, and hydrogen peroxide scavenging methods. The findings demonstrated that the inclusion of flavonoids and tannins in the formulations caused their scavenging activity to increase with concentration. The produced cream can be utilised for wound healing since both antibacterial and antioxidant activities are present. In order to assess a polyherbal cream's physical properties, in-vitro antioxidant activity, and antibacterial effectiveness in comparison to a commercial formulation (5% w/w Betadine), an attempt was made to make the cream. This study's overall findings indicate that this polyherbal antibacterial cream is effective.

Keywords: Staphylococcus aureus, Pseudomonas sp., and Bacillus sp, Betadine, Polyherbal.