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FORMULATION & EVALUATION OF TRANSDERMAL PATCHES OF BUCLIZINE DIHYDROCHLORIDE
Asst Prof. Sagar Suresh Jadkar*, Prof. Sujit T. Karpe, Krishna Rajesh Chhoda, Insha Nashir Deshmukh, Shravani Ashok Gawali, Renuka Sanjiv Adsul, Ashwini Vijay Tikate, Bhavana Balasaheb Pawar, Aditya Pradip Patil
ABSTRACT Transdermal drug delivery has made an immense contributions in pharmaceutical field. It's a patch that delivers a specific amount of medication through the skin into the bloodstream. The main advantage of the transdermal patch is that drug delivery takes place directly into the systemic circulation, bypassing the gastrointestinal system and thus avoiding a first-pass effect in the liver. One advantage of the transdermal route of drug delivery over other types of drug delivery is that the patch allows a controlled release of the drug into the patient, usually through a porous membrane that covers a drug reservoir or melts it. Thin layers of medicine are embedded in a binder using body heat. The present investigation aimed to construct buclizine dihydrochloride transdermal films, using the mercury substrate method, and to evaluate physicochemical parameters such as thickness, weight change, moisture absorption, moisture content, folding strength and drug content value. Three transdermal patches were prepared using different concentrations of ethyl cellulose. It was concluded that as the polymer concentration increased, the thickness of the patch, weight uniformity and folding strength also increased. The percentage of moisture and the percentage of moisture absorption decreased with increasing polymer concentration. Keywords: Transdermal Patch, Skin, Buclizine Dihydrochloride, Ethyl cellulose. [Download Article] [Download Certifiate] |