Abstract

SYNTHESIS AND ANTIBACTERIAL SCREENING OF 4-(3-(5-BROMOTHIOPHEN-2-YL)-1-(4-CHLOROPHENYL)-1H-PYRAZOL-4-YL)-3- CHLORO-1-(ARYL) AZETIDIN-2-ONE FROM SCHIFF BASES CONTAINING PYRAZOLE MOIETY.

S. V. Manohare* and S. S. Thakare

ABSTRACT

A new series of 4-(3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4-yl)-3- chloro-1-(aryl) azetidin-2-one was prepared from pyrazole containing Schiff bases,1-(3-(5-bromo thiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4- yl)-N-(aryl)methanimine. 1-(3-(5-bromo thiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4- yl)-N-(aryl)methanimine were prepared from 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde and aromatic amines. The structures of newly synthesized compounds were confirmed on the basis of IR, 1H NMR and Mass spectroscopy data. All newly synthesized compounds were screened for their antibacterial activity against four microorganisms: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. All compounds showed nearly good to better activity against the test organisms. The synthesized compounds were significantly active against Klebsiella pneumoniae and compounds 3a, 3b and 3l were highly active, showing zone of inhibition 18, 16 and 16 mm respectively.

Keywords: Pyrazole, Schiff bases, 2-Azetidinones, Antibacterial Activity.