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SYNTHESIS AND ANTIBACTERIAL SCREENING OF 4-(3-(5-BROMOTHIOPHEN-2-YL)-1-(4-CHLOROPHENYL)-1H-PYRAZOL-4-YL)-3- CHLORO-1-(ARYL) AZETIDIN-2-ONE FROM SCHIFF BASES CONTAINING PYRAZOLE MOIETY.
S. V. Manohare* and S. S. Thakare
ABSTRACT
A new series of 4-(3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4-yl)-3- chloro-1-(aryl) azetidin-2-one was prepared from pyrazole containing Schiff bases,1-(3-(5-bromo thiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4- yl)-N-(aryl)methanimine. 1-(3-(5-bromo thiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazol-4- yl)-N-(aryl)methanimine were prepared from 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde and aromatic amines. The structures of newly synthesized compounds were confirmed on the basis of IR, 1H NMR and Mass spectroscopy data. All newly synthesized compounds were screened for their antibacterial activity against four microorganisms: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. All compounds Keywords: Pyrazole, Schiff bases, 2-Azetidinones, Antibacterial Activity. [Download Article] [Download Certifiate] |