Abstract

A BRIFE REVIEW ON VITILIGO

Sharvani Hugara*, Sumanji Bala and Jayashree B. Gaja

ABSTRACT

Vitiligo is one of the skin diseases in which pigmentation (white patches on the skin) over the skin. There are different types of vitiligo based on segmental and non-segmental patches. The pathophysiology of the disease is not well understood, but common factors include melanocytes, oxidative stress, and poor regulation of the autoimmune response. Vitiligo affects patients socially and psychologically. Approximately 0.5-2% of worldwide people suffered from vitiligo including children and adult). Various studies have been conducted on the treatment of vitiligo. Early studies disclose that melanocyte stress produces damage-associated molecular patterns that activate innate immunity, however connecting stress to organ-specific inflammation. Genetic studies in vitiligo assist a role for stress, innate immunity, and adaptive mechanisms. In this article, we focus on brief various different types of vitiligo, pathophysiology and treatments there are in that most are effective and safe.

Keywords: Vitiligo, non-segmental (NSV), segmental (SV) and CD8+ T cell, HSP70.