Abstract

EFFECT OF ROSE HIP EXTRACT ON SPATIAL MEMORY IN RATS AND CORRELATION WITH HIPPOCAMPAL EXPRESSION OF PHOSPHORYLATED PROTEIN KINASE C

Khushboo Gupta* and Deepa Bajetha

ABSTRACT

Search for newer plant derived medicinal is always on. Rose hip plant is the plant showing promising potential. Reverse pharmacology and transdisciplinary exploratory studies on rose hip are increasingly being studied these days. In this study seven group of animals were assessed with different dose levels were assessed for their effects on spatial memory by using Morris water maze and radial arm maze. A significant increase in TSTQ and decrease in escape latency time was observed in test groups as compared to memory impaired and control group. Also significant increased expression of protein kinase C was observed in test groups as compared to memory impaired group.

Keywords: Rose Hip, Spatial Memory, Hippocampus, RT-PCR, Transfer Latency.