Abstract

COMPARATIVE IN VITRO EVALUATION OF COMMERCIAL ACECLOFENAC TABLETS

Mrs. Manali. M. Bhide*, Mr. Sachin. A. Nitave

ABSTRACT

Aceclofenac (ACL), is a synthetic new NSAID, which has been widely used in treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis with minimum side effects. Since Aceclofenac tablet is not an official product of I. P. and practically insoluble in water, it was thought necessary to carryout in vitro testing of the commercial products with special attention to dissolution rate studies. Three different brands (A, B & c) of Aceclofenac tablets 100 mg manufactured in India were evaluated for nine in vitro parameters, both official and non-official, viz., uniformity of weight, dimensions, hardness test, friability test, disintegration test, dissolution test and assay. The dissolution test was carried out in phosphate buffer pH 7.5. The study on dissolution profile revealed that product A had faster dissolution rate while product C has slowest dissolution rate. All the products met the requirements as per general specifications of Indian pharmacopoeia for tablet formulation. Assay value lies within the limit of 90% to 110%.

Keywords: Aceclofenac, Evaluation, Dissolution rate, friability, Assay etc.