Abstract

LIPOSPHERES: A BRIEF REVIEW ON OPTIMISTIC LIPID BASED DRUG DELIVERY SYSTEM

Aparna S. Musale*, Mayur B. Patil, Sagar R. Wagh, Tanvir Shaikh, Rajendra D. Wagh

ABSTRACT

A layer of phospholipid molecules buried on the surface of lipospheres, which have a particle size range between 0.01 and 100 m, stabilises their solid hydrophobic lipid core (triglycerides). Hydrophobic and hydrophilic medications can be delivered using the lipospheres delivery system, which is an appropriate carrier system. The utilisation of lipids as new carriers for pharmacological moieties is currently the subject of extensive research. Lipid-based drug delivery systems, such as solid lipid nanoparticles and lipospheres, are being developed as alternatives to "polymer-based delivery systems" because of the growing toxicity-related worries about monomers after intracellular processing of polymers and the alluring advantages offered by lipids as carriers. New drug delivery technology called lipospheres was created primarily for parenteral systems. Due to their lipophilic character, the majority of recently discovered medicines (almost 40–45%) have poor water solubility and low bioavailability. The formulation of lipospheres, factors affecting its quality attribute, drug loading processes, evaluation of lipospheres, and difficulties encountered during their development are all covered in detail in this article.

Keywords: Triglycerides, nanoparticles, Lipospheres, bioavailability, hydrophilic drugs.