Abstract

A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF AZELNIDIPINE AND CHLORTHALIDIONE IN PHARMACEUTICAL DOSAGE FORM

Malleshappa N. Noolvi and Kosada Upasna*

ABSTRACT

Hypertension, another name for high blood pressure, is a common condition that is characterised by abnormally high blood vessel pressure. A lot of people suffer with hypertension (HT), particularly as they get older. It is a significant risk factor for cardiovascular mortality and morbidity but is not a disease in and of itself. Azelnidipine and Chlorthalidone, two newer medications, are used to improve hypertension activity. combo available on the market that reduces hypertension. This mixture was created to enhance treatment for Stage II hypertension. Ca2+ channel blocker Azelnidipine's chemical formula is 3- [1-(Benzyldrylazetidin-3-yl] 5-isopropyl-2-amino-6-methyl-1-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate. A diuretic called chlorthalidone is used to treat hypertension or edema brought on by illnesses like heart failure, kidney failure, cirrhosis of the liver, oestrogen medication, and other conditions. Chemically 2-chloro-5-(1-hydroxy-3-oxo-

Keywords: Azelnidipine; Chlorthalidone; Analytical Method; UV Spectrometry; HPLC Hypertension.