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TRANSMISSION RAMAN SPECTROSCOPY (TRS) AUTHENTICATION OF API IN ANTIBIOTIC DRUG LIKE AZITHROMYCIN.
Muskan Kesharwani*, Mr. Sachin Kumar Jain and Mrs. Sudha Vengurlekar
ABSTRACT Raman spectroscopy provides molecular information about pharmaceutical drugs like anti-bacterial drug like azithromycin. The spectroscopy-based technique has an edge over the traditionally existing techniques and can overcome almost all the major issues faced by the traditional methods. Due to its unique benefits, the Raman spectroscopy, in recent years, has been suggested as a potential tool for chemical identification of the sample (e.g. API determination) during drug manufacturing as well as post manufacturing. Although routinely used configuration of Raman spectroscopy known as back-scattered configuration showed its utility in identification of many drugs including the present one, its performance is limited till few hundreds of micrometers of depths beneath the tablet surface. This is a major hurdle in using the technique for coated tablets. This is because measured Raman signal would be primarily due to coating of the tablet and the Raman signal actually belonging to the API of the tablet would be unrevealed. This particular problem can be overcome by using transmission Raman spectroscopy. In this report, both back-scattered and transmission modes of Raman spectroscopy are used for molecular characterization of anti-bacterial drug such as azithromycin. It has been found that transmission Raman spectroscopy is less susceptible to the Raman signatures of coating material and therefore can be used in API determination of azithromycin. Keywords: Azithromycin, Raman spectroscopy, Transmission Raman spectroscopy. [Download Article] [Download Certifiate] |