Abstract

AN UPDATED REVIEW ON TRANSDERMAL PATCH

Abbas Ali*, Munikoti Lakshmi Kavya, Brahmaiah Bonthagarala, M. Mohan Varma, K.S. Nataraj

ABSTRACT

Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review article provides an overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across human skin, permeation enhancers, and various components of transdermal patches, types of transdermal patches, methods of preparation and its methods of evaluation. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems. This review article covers a brief outline of the various components of transdermal patch, approaches of transdermal patch, evaluation of transdermal system.

Keywords: Transdermal patch; Drug Delivery; skin permeation; evaluation.