Abstract

TRANS TYMPANIC DRUG DELIVERY SYSTEM FOR THE TREATMENT OF EAR DISEASE

Sujeet Kumar Sharma, Sinayak Kumar Dubey, Dr. Dinesh Kumar Sharma, Dr. Deepak Kajla, Mithlesh, Deepak Kumar Yadav, Arghya Majumdar

ABSTRACT

The potential for these protective medicines to impair the chemotherapeutic effectiveness of the principal therapies restricts the systemic administration of protective agents to treat drug-induced ototoxicity. This is particularly true for the medication cisplatin, whose anticancer effects are muted by antioxidants that offer sufficient protection against hearing loss. If used systemically, other existing or hypothetical otoprotective medications could cause a similar issue. High concentrations of these substances may be present locally with few systemic negative effects if other biologicals or protective agents were applied directly to the cochlea. In this article, we present a transtympanic approach of medication or biological reagent administration to the cochlea that should improve fundamental research on the cochlea and offer a straightforward mechanism for guiding the use of otoprotective medicines in clinical settings. This paper describes a strategy for trans-tympanic medication administration and gives examples of how this approach has been utilised effectively to treat cisplatin ototoxicity in test animals.

Keywords: Medicine, Issue 133, Ototoxicity, Cochlea, Trans-tympanic, Cisplatin, NOX3, STAT1, TRPV1.