Abstract

FORMULATION AND EVALUATION OF GASTRO - RETENTIVE FLOATING MICROSPHERES OF AMILORIDE HCl

Suraj Kumar Sah*, Ms. Anupriya Adhikari and Dr. Shivanand Patil

ABSTRACT

The present work by Formulation and Evaluation of Gastro retentive Floating Microsphere plays a highly significant role as particulate drug delivery method. Particle sizes for microspheres range from 0.1 to 200 µm, and they can be administered orally, parenterally, nasally, ophthalmologically, transdermal, colonically, etc. Site-specific targeting and enhanced release kinetics are just two of the issues that have been solved through recent advances in microspheres, including those that are mucoadhesive, hollow, floating, microballoons, and magnetic. Microspheres will play a key role in novel drug delivery in the future by fusing different new methods, particularly sick cell sorting, genetic materials, safe, targeted, and effective drug delivery. Hydroxypropyl Methyl Cellulose, polyvinyl pyrrolidone, and ethyl cellulose were used in varying concentrations to give the floating microspheres of amiloride HCl release-controlling properties by increasing their bioavailability. Lactose was used as a diluent and sodium bicarbonate served as an effervescent agent. By using a solvent evaporation method approach, the gastro-retentive Floating Microsphere of Amiloride HCl was created. The generated microsphere indicated good Floating Strength and remained buoyant in the sustained released medium for 24 hours. For systemic delivery of amiloride, a potassium-sparing diuretic and antihypertensive medication, through the oral route, a gastro retentive floating microspheres drug delivery system was developed. The different ratios of ethyl cellulose and hydroxy propyl methyl cellulose K-100, sodium lauryl sulfate, sodium bicarbonate, and ethanol. The weight, thickness, percentage of moisture absorbed and lost, surface pH, folding resistance, content homogeneity, in vitro residence time, in vitro release, and ex vivo penetration of the microspheres were all assessed.

Keywords: Amiloride HCL, floating Microspheres, Hydroxypropyl methyl Cellulose k-100.