Abstract

A RETROSPECTIVE STUDY OF NEUTROPHIL LYMPHOCYTE RATIO (NLR) AND PLATELET LYMPHOCYTE RATIO (PLR) AS A PREDICTIVE BIOMARKER IN PATIENTS WITH DIABETIC KIDNEY DISEASE AT A TERTIARY CARE HOSPITAL

Dr. Kameshwaran S., Carolin J., Raghul S., *Saranya Devi K. and
Dr. Jayakumar C.

ABSTRACT

Diabetes mellitus causes serious complication such as diabetic kidney disease. Thus, there is a need for early prediction of DKD. The aim of the study was to evaluate whether Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocytes Ratio (PLR) can be a predictive biomarker in patient with Diabetic Kidney Disease. A retrospective study was conducted among diabetic patients of age >30 years with normal renal function and diabetic patients with early DKD. A total of 102 patients were included in the study. The patient demographic and hematological parameters were collected and statistically using t-test, pearson’s correlation and ROC curve analysis methods. Our study showed the significant difference between the groups in terms of Neutrophil Lymphocyte ratio (p=0.000) and Platelet Lymphocyte ratio (p=0.000). Receiver Operating Characteristic curve analysis demonstrated an area under curve (AUC) of 0.854 for Neutrophil Lymphocyte ratio (sensitivity and specificity of 84.3% and 78.4%, p=0.00) and 0.892 for Platelet Lymphocyte ratio (sensitivity and specificity of 82.4% and 80.4%, p=0.00). The study concluded that NLR and PLR are cost effective, more sensitive and non-invasive biomarkers which can be served as an early predictor of diabetic kidney disease.

Keywords: Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Diabetic Kidney disease.