Abstract

A RESEARCH ARTICLE ON A NEW GENERATION OF POLYMER NANOPARTICLES FOR DRUG DELIVERY

*Shaikh Imran, Rizwan Pathan, Sarfaraz Bagwan, Tanvir Patel, Vasim Shaikh

ABSTRACT

Polymeric nanoparticles (NPs) are particles within the size range in between 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. Nanoparticles are mainly using as drug carrier systems is to control the delivery of the drugs including their biodistribution. During the last decade, it was clearly demonstrated that surface properties of nanoparticles were the key factor which determined the in vivo fate of such a carrier. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. One of the applications considered in this work was to use these nanoparticles coupled with haemoglobin as an oxygen carrier. Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Interestingly the biological properties of the polysaccharide immobilized on the nanoparticle surface can be preserved opening very interesting perspectives for such nanoparticles. This method also offers a new strategy for the design of modular biomimetic nanoparticles as drug carrier systems with multiple functions.

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