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A PROSPECTIVE OBSERVATIONAL STUDY ON THE EFFICACY OF FORMOTEROL / BUDESONIDE VERSUS FORMOTEROL / GLYCOPYRRONIUM & TO ASSESS THE QUALITY OF LIFE IN PATIENTS WITH COPD A PILOT STUDY
Aswini B. S., Keerthana M., Sujithra Sukumaran S., Subash Chandran M. P.*, Neethu Mohan, Karthika Lal B. and Prasobh G. R.
ABSTRACT Background: Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable chronic lung disease which affects men and women worldwide. Formoterol is a LABA, decreases resistance in the respiratory airway and increases airflow to the lungs. Budesonide is a corticosteroid, has a potent anti-inflammatory activity. Glycopyrronium is a LAMA, competitively blocks muscarinic receptors thus inhibiting cholinergic transmission. Spirometry is the essential test to assess how well your lungs work by measuring how much air you inhale, how much you exhale & how quickly you exhale. St. George Respiratory Questionnaire (SGRQ) is a disease-specific instrument designed to measure impact on overall health, daily life & perceived well-being in patients with obstructive airways disease. Methods: The study was carried out in 25 patients with COPD. The study was conducted by categorising them into two groups, 13 patients taking Formoterol/Budesonide and 12 patients taking Formoterol/Glycopyrronium. The efficacy of drugs are assessed using spirometry and health related QOL is assessed using SGRQ-C. Result: By using spirometry, it was found that Formoterol/Glycopyrronium showed improvement in patients. A significant increase in the QOL was found in patients taking Formoterol/Glycopyrronium using SGRQ-C. Conclusion: It was concluded that, Formoterol/Glycopyrronium is slightly more efficient than Formoterol/Budesonide. There is a significant improvement in the QOL scoring in patients taking Formoterol/Glycopyrronium when compared to that of patients taking Formoterol/Budesonide. Keywords: Formoterol, Budesonide, Glycopyrronium, Spirometry, SGRQ, QOL, FEV1/FVC ratio. [Download Article] [Download Certifiate] |