Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC TOPICAL EMULGEL

Kalamkar R. D.* and Satpute J. B.

ABSTRACT

The human being, since many ages get experienced with various types of diseases influencing their health and prosperity. The effort to cure diseases has been driving in the discovery of various medications, drug and delivery systems. To get a remedial response of drug required for treatment of illness different routes of administration are taken after. Route of administration depends on sort and seriousness of the disease. Over the past three decades, controlled drug delivery has become increasingly important in the pharmaceutical industry. The surface of human skin is known to contain, on an average, 10-70 hair follicles and 200 to 250 sweat ducts on every cm2of the skin area. Skin is a very difficult barrier to the ingress materials allowing only small quantities of drug molecules to penetrate over a period of time. Transport of hydrophilic or charged molecules is especially difficult attributable to the lipid-rich nature of the stratum corneum and its low water content; this layer is composed of about 40% lipids, 40% protein, and only 20% water.[1]

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