Abstract

FORMULATION AND EVALUATION OF GLIMEPIRIDE TABLET BY IMPROVING AQUEOUS SOLUBILITY OF DRUG USING HYDROTROPY TECHNIQUE

Maseera Kazi*, Sanket M. Gandhi, Dr. R. Barse, Dr. Vijay Jagtap

ABSTRACT

The purpose of this research study was to formulate and evaluate Glimepiride tablet by improving aqueous solubility of drug using hydrotropy technique. The pharmacological response of drug mainly depends on its absorption rate, which in turn depends on drug’s solubility which is an important parameter. Glimepiride is an oral anti hyperglycaemic agent useful in lowering the blood glucose level in normal subjects with type 2 diabetics, has poor aqueous solubility. The poor aqueous solubility of medicament results in decreased bioavailability and insufficient therapeutic effect. In the present research, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug Glimepiride by mixed hydrotropy technique using hydrotropic solutes, such as sodium citrate, sodium salicylate and sodium benzoate. Different ratios of hydrotrops were prepared by solid dispersion technique and optimized was selected for final tablet formulation. To increase the disintegration of the tablet formulation some super disintegrants are used such as crosspovidone and sodium starch glycolate. Preparation of tablet by direct compression and evaluation were done. This study revealed the influence of hydrotropic agents in the improvement of solubility of Glimepiride. Compatibility between drug and excipient examined by FTIR and DSC study and on the basis of all the parameters the conclusion and results were drawn.

Keywords: Pharmacological, Anti hyperglycaemic, Hydrotropy, Bioavailability, Disintegrants.