Abstract

REVIEW ON: “LIPOSOMAL DRUG DELIVERY SYSYTEM”

Phoke S. V.*, Hatkar A. D., Rawat S. S., Kulkarni O. S. and Kadam N. R.

ABSTRACT

Liposomes were the first nanoscale drug to be approved for clinical use in 1995. Since then, the technology has grown considerably, and pioneering recent work in liposome-based delivery systems has brought about remarkable developments with significant clinical implications. Liposome was derived from two Greek words “Lipos” meaning fat, and “Soma” meaning body. Liposome, where spherical-shaped vesicles consist of phospholipids and cholesterol vesicles which are under extensive study as drug carriers for improving the bioavailability and delivery of therapeutic agents. Liposomes have immense ability to prevent the degradation of drugs, reduce side effects and are thus increasingly used for targeted drug delivery. The drugs can either be included inside the aqueous space (hydrophilic drugs) or inside the phospholipids bilayer (hydrophobic drugs) of liposomes for the targeted drug delivery. Considering the importance of liposomes as a drug delivery system, the present review paper tries to look into its details. The entire paper is classified into six parts. The first part is introductory. The second part discusses the classification of liposomes. In the third segment, the structural components of liposomes are detailed. The fourth portion of the paper talks about methods of preparation of liposomes. In the fifth segment, the characterization of liposomes is discussed. The sixth part discusses the application of liposomes and the last part is given to concluding observation.

Keywords: Liposome, phospholipids, bioavailability, hydrophobic.