Abstract

A SYSTEMATIC REVIEW ON INJECTABLE IN-SITU GELLING CONTROLLED RELEASE DRUG DELIVERY

Shubham Dipak Narwade*, Dr. R. B. Wakade, Vaibhav P. Patange, Shivshankar G. Kadam, Ankita M. Deshmukh and Amol R. Kadam

ABSTRACT

The administration of poorly bioavailable drugs through the parenteral route is considered the most effective method for drug delivery. Parenteral delivery provides a rapid onset of action, even for drugs with a narrow therapeutic window. However, maintaining systemic drug levels requires repeated injections, which can cause discomfort to the patient. To address this issue, drugs can be designed as a system that controls drug release, even through parenteral delivery. This approach can improve patient compliance and be cost-effective. One such system is the injectable in-situ gelling system, which is biodegradable. This system offers attractive opportunities for drug delivery of proteins, anti-cancer agents, and NSAIDs. It could also potentially extend the patent life of these drugs. This article explores the use of the injectable in-situ gelling system for prolonged-release parenteral drug delivery, including the strategies for preparation, potential benefits, mechanisms of action, and in-vitro testing methods.

Keywords: Injectable In-Situ Gel, Biodegradable Polymer, Injectable Polymeric System, Phase Separation.