Abstract

POTENTIAL ROLE OF PI3KINASE’S IN CANCER TREATMENT

*Gandhi Parikshit, Dhande Swati, Kadam Vilasrao

ABSTRACT

The phosphoinositide 3-kinases (PI3-kinases) are a family of lipid kinases that play a important role in the regulation of many cellular processes such as proliferation, survival, carbohydrate metabolism, and motility.Although some PI3-kinase activity is likely to be essential for cellular health, the PI3-kinases are a rather diverse group of enzymes for which there is increasing evidence of functional specialisation. This opens up the possibility of developing isoform-selective inhibitors that could be used to treat cancer with limited toxicity. The phosphoinositide 3-kinase(s) (PI3K) are a group of protein that catalyse the phosphorylation of the 3-OH position of phosphoinositides and generate lipids that control a wide variety ofintracellular signalling pathways. They are classified into three families according to their structure and substrate specificity and arethought to have distinct biological roles. The numerous components of the PI3K pathway play acrucial role in the activation of inflammatory mediators, inflammatory cell recruitment, immune cell function, airway re-modelling, and corticosteroid insensitivity in chronic inflammatory respiratory disease. Thus the current information of the review article is tried to compile the data in order to get the good anticancer drugs.

Keywords: PI3K inhibitors, Mechanism of PI3K enzyme, Targets of PI3K, etc.