Abstract

NOVEL APPROACHES FOR NASAL DRUG DELIVERY SYSTEM

Deepak Kumar*, Nitan Bharti Gupta, Rajesh Gupta, Hardeep Kaur, Simran and Dalip Kumar

ABSTRACT

Today, there is a lot of interest in the use of the nasal route for the delivery of difficult medications including tiny polar compounds, vaccines, hormones, peptides, and proteins. The nasal cavity is ideally suited for systemic drug delivery because of its high permeability, high vasculature, low enzymatic environment, and avoidance of hepatic first pass metabolism. Due to the need for quick and/or precise drug targeting of the brain, numerous drug delivery devices for nasal application of liquid, semisolid, and solid formulation are being researched. These diseases include Parkinson's disease and Alzheimer's disease. The distribution of biotechnological products such proteins, peptides, hormones, and DNA plasmids for DNA vaccines to provide increased bioavailability is ideally suited for it.

Keywords: First pass metabolism, Bioavailability, Nasal cavity, Olfactory region.