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A RESEARCH ARTICLE ON THE FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS USING DIFFERENT POLYMERS CONTAINING THEOPHYLLINE & ETOPHYLLINE AND THEIR FORMULATION ASPECTS
Renu Tiwari*, Jiya Ul Hak and Vatan Chaudhary
ABSTRACT In the current study, wet granulation was used to create SR matrix tablets of theophylline and etophylline, incorporating various polymer combinations and fillers in an effort to increase therapeutic efficacy, decrease the frequency of administration, and improve patient satisfaction. Resources and techniques Hydrophilic polymer, HPMC, sodium alginate, and starch were used as fillers to create SR tablets in a variety of combinations. Preformulation experiments were performed on the medication excipient mixtures. The prepared tablets (F1-F6) passed the official standards after being assessed for various physicochemical characteristics. There was no interaction between the medication and the polymers, according to FTIR measurements. Stability analyses on the optimised formulations (F3) revealed no significant changes in the drug content, physicochemical characteristics, or release pattern. The medication and formulation were assessed using the RP-HPLC technique. The in vitro release investigations show the following outcomes: drug in combination with HPMC were found to be effective in delaying the release of pharmaceuticals by up to 87% over a lengthy period of time, which verifies the extended release profile of formulation (F3) after 6 hours as compared to marketed formulation. Theophylline and etophylline SR matrix tablets demonstrated higher absorption, effectiveness, and potency as compared to established standards.[7] Keywords: Sustained release, Theophylline, Etophylline Matrix tablet, HPMC (Hydroxy propyl Methyl cellulose). [Download Article] [Download Certifiate] |