Abstract

NANOPARTICLES INCORPORATED SPHERULES IN ORAL DRUG DELIVERY SYSTEM: A REVIEW

Akshada Chavhan*, Tejashree Idhole, Nitin Padole, Pankaj Dhapake, Nilakshi Dhoble, Jagdish Baheti

ABSTRACT

Over the past three decades, there has been great interest in developing drug delivery systems using nanoparticles (NPs) as carriers for small and large molecules. Nanoparticles can be defined as materials with at least one dimension (1D) in the nanometer range. It can exist in various forms such as forming nanovesicles, nanospheres, nanofibers, etc. Targeting drug delivery to disease lesions is one of the most important aspects of drug delivery systems. Nanoparticles are loosely classified into different categories according to their morphology, size and chemical properties. Carbon-based, metal-based, and polymer based nanoparticles. Spheronization or spheroidization is a fast and flexible process or is processed into small spheres or spheroids with diameters ranging from approximately 0.5 mm to 1 mm, while spheroidization is 0.6mm to 1.2 mm. Spheronization is the most widely used method for manufacturing beads (spherical particles) and produces beads with high drug loading capacity and excellent flow properties compared to granules and pellets. The goal of this article is that nanoparticles and beads for drug delivery enhance therapeutic efficacy and reduce side effects and toxicity. Additionally, the beads may modify their surface properties by polymer film coating. Surface coating improves functional properties. This review focus on nanoparticles, their manufacturing processes, types and evaluation parameters, and also on beads, their manufacturing processes and evaluation parameter.

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