Abstract

BIOAVAILABILITY ENHANCEMENT OF SELECTED CALCIUM CHANNEL BLOCKER BY USING SOME HERBAL BIOENHANCER

Jnanendra Thakur*, Sachin Kumar Jain and Neetesh Kumar Jain

ABSTRACT

Aim: The aim of the present aim is to study Bioavailability Enhancement of Selected Calcium Channel Blocker by Using Some Herbal Bioenhancer. Material & Methods: Five ml of 0.1 N HCl, pH 4.5 acetate buffers, pH 6.8 phosphate buffers and distilled water were taken into four different test tubes separately and then excess quantity of the drug (around 50 mg) was added to get saturated solutions. The test tubes were kept aside for 24 hrs and filtered through 0.23 μm membrane filter. The samples were suitably diluted and analyzed at 295 nm by using UV-Visible spectrophotometer. Telmisartan-luteolin complexes of 1:1 molar ratio were prepared by placing 1g of telmisartan and 2.21g of luteolin in a mortar and mixed thoroughly by trituration. Then complexes obtained were sieved by using sieve no#100. Telmisartan-luteolin complexes of 1:1 molar ratio were obtained by dissolving 1g of telmisartan and 2.21g of luteolin in ethanol/water mixture (1:1) to get a clear solution. Dissolution studies on the pure drug, and the inclusion complexes prepared by different methods were performed in pH 7.5 phosphate buffer using USP TDT-08L dissolution test apparatus (Electrolab, Mumbai, India) with a paddle stirrer. Results: Dissolution studies on the pure drug, and the inclusion complexes prepared by different methods were performed in pH 7.5 phosphate buffer using USP TDT-08L dissolution test apparatus (Electrolab, Mumbai, India) with a paddle stirrer. Conclusion: The dissolution rate was found to be influenced by the method employed and the ratio used to prepare the inclusion complexes. The telmisartan complexes formulated with kneading technique and having 1:3 (telmisartan: quercetin) ratio showed highest dissolution rate among the other formulations.

Keywords: Bioavailability Enhancement, Calcium Channel Blocker, Herbal Bioenhancer, Water-soluble molecules, Cytochrome P450 (CYP).