Abstract

EFFECTS OF PURIFIED TICKS SALIVA TOXINS ON GLYCOGEN LEVEL IN LIVER, ATRIA, VENTRICLE, GASTROCNEMIUS AND RECTUS ABDOMINIS MUSCLES OF ALBINO MICE

Nidhi Yadav and Ravi Kant Upadhyay*

ABSTRACT

In the present investigation, in vivo effects of purifiedticks saliva toxin were evaluated on glycogen level in rectus abdominis, gastrocnemius muscle, atria and ventricle of albino mice and muscle glycogen. A significant elevation was observed in glycogen level in liver 69.28% to 67.94% rectus abdominis 80.88% to 82.22% gastrocnemius 85.71% to 66.32% Atria 73.42% to 49.09% and in ventricle 76.25% to 69.78%. Results clearly indicate saliva toxins induced toxic stress on body tissues mainly muscles, atria and liver of albino mice. In present study decreased glycogen content was associated with heavy toxic stress imposed by toxins to compensate extra burden of cellular toxicity and metabolic demand. Glycogen, therefore, is more than a nutrient storage macromolecule; it is a key regulator of metabolism and body physiology.

Keywords: Rhipicephalusmicroplus, glycogen, rectus abdominis, gastrocnemius, muscle, atria, ventricle.