Abstract

SOLUBILITY ENHANCEMENT OF LULICONAZOLE BY SOLID DISPERSION

Pallavi Kaple*, Sudha Mahaka Rini Punathil, Satishkumar Mehetre and
Rakhi Awadhiya

ABSTRACT

solubility enhancement of Luliconazole by using solid dispersion. Solid dispersion was successfully prepared by using melting method and by using coat Polyethylene glycol (PEG) Firstly preparation of the calibration curve of Luliconazole in Methanol and the trial batches of was prepared by keeping drug polymer ratio 1:1,1:2,1:3,1:4,1:5,1:6 of PEG varying polymer ratio of PEG (respectively) The prepared trial batches has good micromeritic properties such as average particle size. The tapped density value ranged from 0.46-0.36 g/cm3 for trial batches of Luliconazole batches the bulk density in between 0.36-0.33 g/cm3 for trial batches of solid dispersion of different polymer and different ratio From the Solid dispersion batches (1:4), batch show better results of micromeritics properties as compared to the other, from this result we can conclude that increase in polymer concentration (especially PEG 6000) increases the powder flow properties of solid dispersion. The solid dispersion drug content was found in a range of 45.86-90.24% which proven the high content uniformity and the maximum drug content in percent was found to be 90.24% which is present in ratio 1:4 in between drug and polymer as we found when we increase the concentration of polymer the drug content is also increased, this is because drug content provides high drug uniformity and distribution in the polymer network during its preparation, also the high drug content depends on the type and nature of the polymer and the method which is used to prepare the solid dispersion this further proof that we selected one of the best methods for drug loading, and there was less chance of drug loss from polymer network. The skin permeation study has been done by using the Franz diffusion cell.

Keywords: The prepared trial batches has good micromeritic properties such as average particle size.