Abstract

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF AQUEOUS EXTRACT OF BUTEA MONOSPERMA L. IN TRITON WR 1339 TREATED HYPERLIPIDEMIC RATS

P. D. Mahure, A.V. Shrirao*, M. Muqitur Rahman, V. S. Chaudhari, N. I. Kochar, A. V. Chandewar

ABSTRACT

Objective: The present work was undertaken to investigate the possible antihyperlipidemic and antioxidant effect of aqueous extract of Butea monosperma L. (BM) flowers on hyperlipidemic rats. Method: Hyperlipidemia was induced in rats by a single intraperitonial (i.p.) injection of Triton WR 1339 (400 mg/kg) and it showed sustained elevated levels of serum cholesterol and triglyceride. The Aqueous extract of Butea monosperma L. flowers (AQ-BM) (200,400 and 600 mg/kg/day) was administered to normal and hyperlipidemic rats for 14 days. Result: Serum and liver tissue were analyzed for lipid profile and antioxidants enzymes and the activity was compared to the cholesterol-lowering drug, Atorvastatin (10 mg/kg). Parameters were altered during hyperlipidemia and reverted back to near normal values after AQ-BM treatment or standard drug Atorvastatin. Lipid peroxidation decreased whereas the activities of superoxide dismutase, glutathione peroxidase and catalase increased in AQ-BM treated rats. Pronounced changes were observed at 600 mg/kg of AQ-BM for 2 weeks and it was comparable to the standard drug Atorvastatin. Conclusion: The current study provides strong evidence that AQ-BM has a remarkable beneficial effect in treating hyperlipidemia and ROS without any side effects at 600 mg/kg/day for 14 days.

Keywords: Butea monosperma L., Hyperlipidemia, Lipid profile, Antioxidant enzyme.