Abstract

MICROSPONGES: AN INEVITABLE TOOL IN DRUG DELIVERY SYSTEMS

Akshara V. Anil*

ABSTRACT

To meet the objectives of optimised efficacy and cost effectiveness of therapy, numerous advancements are implemented in the drug delivery system. The microsponge drug delivery system, which provides controlled release and site specific administration of active components, is one of the most recent, unique, and rapidly evolving technologies. Microsponge drug delivery devices were first created for topical medication delivery and were then adapted for controlled oral drug delivery. Microsponge drug delivery is a patented polymeric system consisting of porous microspheres that resembles that of sponges and size ranges from 5-300μm. Due to qualities including fewer side effects, more stability, better formulation flexibility, and enhanced product performance, this method is becoming a desirable option for topical medication administration. Wide range of active ingredients can be loaded into the microsponges like emollients, fragrances, anticancer, antifungal etc. Both drugs and cosmetics can entrap into the pores of microsponges. The drug release is aggravated by the change in pH, temperature, solubility and pressure. Microsponges overcome the drawbacks of conventional formulations by release the drug gradually and in controlled manner to the skin. It has a variety of uses in the delivery of oral, topical, ocular and biopharmaceuticals. The current review provides information on microsponge technology, programmable release mechanisms, formulation methodologies, evaluation and applications.

Keywords: Microsponge, Controlled release, Oral delivery, Topical application.