Abstract

NATURAL PRODUCT-BASED NANOMEDICINE IN TREATMENT OF INFLAMMATORY BOWEL DISEASE

Harshit Mishra*, Rita Saini and Shivanand M. Patil

ABSTRACT

Many synthetic drugs and monoclonal antibodies are currently used to treat inflammatory bowel disease (IBD). However, all these cause serious side effects and cause many problems with long-term use. Numerous in vitro and in vivo experiments have shown that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. In addition, many of them modulate enzyme activity, reduce oxidative stress, and regulate pro- inflammatory transcription factors and cytokine release. The translational significance of natural nanomedicine and future strategies for investigating natural product- based nanomedicine are discussed. Our main objective in this review is to summarize the application of nanoparticle- encapsulated phytochemicals and macromolecules for the treatment of IBD and IBD-related colorectal cancer.

Keywords: Inflammatory bowel disease, Crohn‘s disease, Ulcerative colitis, phytochemicals, Macromolecules, Inflammation, Nanoparticles, Nanomedicine