Abstract

AMOXICILLIN MUCOADHESIVE TABLET: FORMULATION AND CHARACTERIZATION

*Dhruba Sankar Goswami¹, Manoj Sharma ²

¹Pacific Academy of Higher Education and Research University, Udaipur
²Shri Ramnath Singh Mahavidyalaya (Pharmacy) Gormi, Bhind (M.P.)

ABSTRACT

Objective of this research was to design mucoadhesive tablets of Amoxicillin trihydrate with moringa gum as a natural mucoadhesive polymer. This drug having low biological half life and the dosing frequency is very high. Natural gums are being used due to their abundance in nature, safety and economy. So in this present research work was an effort to study the easily available gum obtained from moringa oleifera as mucoadhesive polymer. The present study aims to reduce the patients’ compliance by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine other natural polymers (moringa gum, gum tragacanth and gum acacia) and synthetic polymers (sodium CMC) polymers have been made to prepare total ten formulations. Further, different characterization like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing moringa gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that moringa gum is suitable for preparation of mucoadhesive tablets.

Keywords: Moringa gum, Mucoadhesive, Natural polymer.