Abstract

COLON TARGET DRUG DELIVERY SYSTEM: CONVENTIONAL AND NOVEL APPROCHES

Rajnish Kumar*, Satvir Kaur, Rajesh Gupta, Nitin Bharti Gupta and Rakshit Sharma

ABSTRACT

Colon drug delivery systems have gained significant attention in recent years due to their potential for targeted drug delivery to the colon. Conventional approaches such as pH-dependent systems, time-controlled release systems, and microbially triggered systems have been widely studied for colon-specific drug delivery. However, these systems have certain limitations such as variable pH conditions in the colon, lack of specificity for microbial enzymes, and limited drug loading capacity. To overcome these limitations, novel approaches such as nanotechnology-based drug delivery systems, prodrug approaches, and bioadhesive systems have been developed. Nanotechnology-based systems have the advantage of increased stability and improved drug loading capacity. The prodrug approach involves the modification of a drug molecule to form a prodrug that can be activated in the colon by microbial enzymes. Bioadhesive systems can improve drug retention in the colon by adhering to the mucosal surface. Overall, colon drug delivery systems have the potential to improve the therapeutic efficacy and reduce the side effects of drugs. The development of novel approaches can overcome the limitations of conventional approaches and provide more efficient and targeted drug delivery to the colon.

Keywords: Colon, Colon drug delivery system, Conventional and Novel approaches for CDDS.