Abstract

A REVIEW STUDY ON AYURVEDIC MEDICINAL PLANTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE

Nalini Devi Dammati*, Boddu Srilakshmi, Shaik Moina, Yalavarthi Lasya Chowdary, Guntupalli Namitha, Gumma Surekha, Gona Navya sree and Battina Rohitha

ABSTRACT

Nootropic activity is mainly intended to prevent Alzheimer’s that cause selective loss of cholinergic neurons in Hippocampus and Basal forebrain. The TAU (tubulin associated unit) P paired and deposited intracellularly as twisted paired helical filaments known as neurofibrillary tangles. When cell dies, these filaments aggregate as extracellular insoluble neurofibrillary tangles. Finally leads to neuronal cell death. Plants are an important source of medicine, and they have long been utilized as a traditional therapeutic treatment of a wide range of diseases. Ayurveda is a traditional Hindu medicinal system in which a variety of plants are used as nootropic agents. Nootropic agents are the substances that enhance the levels of acetylcholine in neocortex and hippocampus and inhibit the formation of amyloid plaques. Therefore, they help in memory enhancement. The flavonoids, tannins and steroids present in these plants are mainly responsible for nootropic activity. The current study is a review of the literature on medicinal plants having nootropic properties. It includes 40 plants, their families, species, biological sources and therapeutic uses. This effort aims to assist researchers in the investigation of natural compounds that can be used as nootropic.

Keywords: Tau P, nootropic, alzheimer’s, hippocampus, amyloid plaques, medicinal plants, tannins, flavonoids, steroids.