Abstract

A REVIEW ON VARIOUS ASPECTS OF MOUTH DISSOLVING TABLETS

Amrapali B. Jadhav*, Shital P. Khandagale and Suraj A. Tupe

ABSTRACT

The oral route administration is regarded the most favorable over other routes due to its simplicity, convenience of usage, patient compliance, cost – effectiveness, and painlessness. It is also the safest way of administration. Recent years have seen difficulties with standard dosage forms including patients who are unable to take oral medicament due to dysphasia, unconsciousness, behavioral disorders or CNS abnormalities. So, the first modern alternative to conventional dosage form is to initiate a rapid and swift breakdown in the oral cavity to solve these issues. Mouth dissolving tablets seems to be demanding, promising & one of the most extensively used dosage form over the conventional ones. The development of MDTs aims to provide products with adequate hardness, integrity, taste masking property, pleasant mouth feel, quick disintegration without needs of water within short time period. i.e., ≤60secs. The formulation of mouth dissolving tablets has been potential benefits, especially for pediatric, geriatric, bed – ridden, uncollaborative, and traveling patients who may not have access of water for tablet swallowing. The appropriate weight of tablets, specific disintegration time as well as selection of API’s that meet the criteria of MDT are important requirements during formulation of MDT’s. This review focused on the formulation challenges with mouth dissolving tablets where flavour masking is the key factor in enhancing the patient acceptability of these formulations. This study emphasizes obstacles and the method of preparation, significance and demerits, mechanisms, selection criteria of pharmaceuticals which should be incorporated in MDT’s, challenges as well as recently developed sophisticated formulation approaches of MDT’s, quality control tests of medicament. And also give a brief overview of formulation techniques of MDT’s as well as usage of various excipients are used, both of which crucial for the rapid breakdown of the medicament in mouth cavity following oral administration. Furthermore, the important characteristics of mouth dissolving tablets that are essential for patient compliance and acceptable therapeutic outcomes are discussed.

Keywords: Mouth dissolving, Oro-dispersible, mouth melt, Ora-quick, Advatab.