Abstract

A REVIEW ON MELT GRANULATION TECHNIQUES

Suresh Vurigithi*, P. D. Chandra Vamshi, Brahmaiah Bonthagarala, M. Mohan Varma, K. S. Nataraj

ABSTRACT

In the process of creating pharmaceutical oral dosage forms, granulation is one of the most crucial unit processes. Granulation will enhance flow and compression properties, lessen segregation, increase content uniformity, and get rid of too many tiny particles. The outcomes will be better yields, fewer tablet faults, higher productivity, and less downtime. The collection of tiny particles into larger aggregates is referred to as an agglomeration or granulation. Agglomeration refers to the buildup of small particles into larger aggregates with the help of a binding agent or mechanical force, such as water, starch paste, or roller compaction. Although both terms are similarly defined, inspection of the manufacturing process offers a simple method of differentiating the two aggregation phenomena. This analysis concentrates on the most recent developments.

Keywords: Granulation, Agglomeration, segregation.