Abstract

DISSOLUTION IMPROVEMENT OF ETODOLAC USING MANNITOL BY SOLID DISPERSION METHOD

T. Raja Sekharan*, M. Muthumari, Lanka Gopal and A. Esakiyammal

ABSTRACT

Etodolac is a poorly water-soluble drug, belongs to class II drug; that is, characterized by low solubility and high permeability. It is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-arthritic properties. The aim of the present work was to prepare and investigate the effect of mannitol as a carrier. Etodolac solid dispersions were prepared by co-precipitation method. All the prepared solid dispersions exhibited appropriate percentage yield, drug content, loss on drying and invitro release studies. The carrier did not show any incompatibility when tested using Fourier transform infrared spectroscopy. A faster release was observed in F-4 formulation compared to other formulations. The in vitro release from all the formulations was fitted to the entire kinetics model and it was best described by zero order kinetics.

Keywords: Etodolac, mannitol, solid dispersion, co-precipitation method.